Tag Archives: Isotretinoin

Skin Rashes

Common Skin Rashes

Rashes are abnormal changes in skin color or texture. They usually result from skin inflammation, which can have many causes. There are many types of rashes including:

  • Eczemaa general term that describes several different conditions in which skin is inflamed, red, scaly, and itchy. Eczema is a common skin condition, and atopic dermatitis is one of the most common forms of eczema.
  • Granuloma Annulare – a chronic skin condition that consists of a circular-shaped rash with reddish bumps.
  • Lichen Planus – a common skin disorder that produces shiny, flat-topped bumps. Lichen planus can show up anywhere on the skin but often affects the insides of your wrists and ankles, your back, your lower legs, and your neck.
  • Pityriasis Rosea: a common skin rash that usually is mild. The condition often begins with a scaly, pink patch of skin on your chest or back. Next, you’ll notice one patch of pink skin quickly followed by more. Your skin will be itchy or inflamed.

Causes of Skin Rashes

Rashes come in many forms and common causes include bodily infections, contact dermatitis, and allergic reactions to taking medication. They can be moist, dry, bumpy, cracked, smooth, or blistered. They can be painful, itch, and even change color. Rashes affect millions of people across the world. Some rashes may need no treatment and will clear up on their own, some can be treated at home and others might be a sign of something more serious.

Risk Factors of Skin Rashes

  • Certain medication reactions
  • Allergic reaction (drug reaction, food or animal allergy)
  • Prolonged exposure to heat or irritants
  • Insect bites (spider, mosquito, tick, or flea,)

Symptoms of Skin Rashes

If a rash occurs with the following symptoms, it is important to visit a doctor:

  • Tender regions near the rash
  • A large collection of pus
  • A sore throat
  • Red streaks near the rash
  • Pain in joints
  • If you have had a recent animal or insect bite

Even though the majority of rashes are not a major cause for concern, anyone experiencing the following symptoms should go to the hospital straight away:

  • Severe pain in the neck or head
  • Repeated vomiting or diarrhea
  • Quickly changing coloration on the skin
  • High fever
  • Confusion
  • Difficulty breathing or feeling like the throat is closing up
  • Increasing pain or severe pain
  • Dizziness
  • Swelling of the face or extremities

Treatment for Skin Rashes

There’s no certain way on how to prevent skin rashes, but you can do things to improve your symptoms:

  • Moisturize often
  • Avoid situations that cause sweating and overheating
  • Avoid sudden changes in temperature or humidity
  • Avoid scratchy materials and chemicals such as harsh soaps, detergents, and solvents
  • Reduce stress

Medicine for Skin Rashes

Buy Isotretinoin

Treating Severe Type of Acne

Isotretinoin treats a severe type of acne. It belongs to the class of medication called Retinoid. It is a big problem for youths. Different medicines, capsules, lotion etc. are available in order to get rid of it. But people many a time fail to do so. Isotretinoin is helpful in treating acne and the others fail to improve. It is helpful treating some type of skin cancer and in treating other cancers. It show result in skin disease. It is retinoid that means it relates to vitamin A. This is available in small amount naturally in the body. This type of acne causes painful cyst and nodules, deep in the skin layer.

HISTORY:

Roche laboratories discovered the compound in Switzerland by Werner Bollag in 1960s. This studies was for the treatment of skin cancer. But it was inactive for cancer. It showed benefits in case of acne. In 1975 Gary and Frank Yoder rediscovered the drug to use it in case of cystic acne and published his work. Rochis New drug application got approval from FDA in 1982. He organize a program called pregnancy prevention program. He inform possible defects in the fetus in pregnancy with above pill. His patent for this drug expired. Now many other companies sell cheaper generic version of the drug.

WORKING:

Its exact mechanism is unknown. It is form of vitamin A. It controls the amount of oil released by the oil glands in your skin. This help skin to renew itself in short period. Acne occur due to the increase in the secretion of oil from oil glands. Several studies show that it induces cell death in various cell in the body. This include sebaceous gland cell too. One more studies show that it help the production of NGAL in the skin. This induce death of cell in glands and reduce oil production. Thus the size and oil output decrease. Only isotretinoin can effect major four pathogenic processes in acne. This separates it from other medicines. The significant decrease in P.acne amount leads to the decrease in acne inflammation.

DOSAGE:

A dose of 0.5-1.0 mg/Kg/day reduces the (oil) sebum excretion by 90% within 6 weeks. Dose is dependent on body weight. It is decided by Doctor. It is available in 10 mg and 20 mg tablet. Give it in two divided dose with food for 15 to 20 weeks. Dose is adjusted according to how the disease respond and the side effects occur in the person.

SIDE EFFECTS:

Any drug administered in the body takes time to adjust in the body. This shows some common side effects which don’t need medical attention. They disappear with time. They are;

  • Itching
  • Nausea
  • Weight loss
  • Hair thinning and breakage
  • Dry mouth, ears, throat, anus
  • Changes in the nail and skin texture

It is necessary to check out for major side effects. It can lead serious conditions. They are;

  • Temporary depression
  • Inflammation of liver or pancreas
  • Bone disorders
  • Vision changes
  • Severe diarrhea
  • Continuing headache
  • Abdominal and stomach pain

PRECAUTIONS:

It is necessary to take precaution to take medicine in certain cases. Don’t use this tablet if a person belong to following medical conditions;

  • Person showing allergy to the ingredient in the above drug
  • Children younger than 12 years
  • Teenagers with bone problems or disease
  • In pregnancy, as it can produce fetal defects
  • Breast feeding, as no adequate evidences show its safety
  • Certain drugs can interact with above medicine. Check with doctor and consume with doctors permission.
  • Avoid drinking alcohol and tobacco

Some other medical conditions like

COST OF GENERIC VERSUS THE BRAND NAME OF DRUG:-

The generic drugs are cheaper as compared to brand name drug. They contain same active ingredient as the brand name. It is an effective medicine. The difference between the prices is due to the packaging and the brand name. The generic form of this drug is $0.88 for 20 mg and $0.94 for 10 mg per pill. The cost of brand Accutane is $4.71 for 20 mg per pill and $1.48 for 10 mg per pill.

This represent the difference between the prices of generic versus the brand version of Isotretinoin. It shows visible improvement in the acne.

Acne

Acne vulgaris or commonly known as acne is a chronic, inflammatory skin condition. It often causes pimples and spots on the face, neck, head and chest. It’s most common among teenagers when their sebaceous glands are very active though it affects people of all ages. In the US alone, at least 85% of the people experience acne between the ages of 12 to 24.

Effective treatments are available over the counter but the more severe forms should be treated by a dermatologist.

Types of acne

Acne pimples may vary in level of pain, color and size. The following types are possible:

  • Blackheads: They are black and visible on the skin surface.
  • Whiteheads: They remain under the skin.
  • Pustules: They are red at the base with pus at the top.
  • Papules: Usually small, pink bumps that is visible on the surface of the skin.
  • Nobules: They are solid, large and painful pimples under the skin.
  • Cysts: They are painful and are filled with pus. They can cause scars.

What are the causes of acne?

There are four main factors causing acne. These are:

  1. Bacteria- Propionibacterium acnes that live on the skin can contribute to the infections.
  2. Excess oil production- Increased production of sebum can plug the skin pores. The plugged hair follicle slowly become big and produces bumps. Eventually, the wall breaks allowing bacteria and other harmful substances into the skin.
  3. Clogged hair follicles– The clogged hair follicles allow oil build-up under the skin.
  4. Excess activity of androgen hormone– Excess androgen hormone can cause the oil gland under the skin to grow.

Other factors that may cause and worsen acne are:

  • Greasy cosmetics
  • Menstruation
  • Dirt
  • Foods
  • Hormonal change
  • Stress
  • Genetic reasons
  • Certain medications
  • Occupations
  • Diet

What are the signs and symptoms of acne?

The signs and symptoms of acne depend upon the severity of the conditions:

  • Blackheads
  • Whiteheads
  • Pimples
  • Painful lumps under the skin
  • Lumps that are filled with pus under the skin.

The adverse effect of the problem

Acne problem can have both psychological and physical effects. People with recurrent acne can experience the following:

  1. Low self-esteem
  2. Image problems at school and work
  3. Attitude problems
  4. Problems having friends
  5. Depression

How can I prevent acne?

Here are some prevention tips for acne-prone skin.

  • Do not scrub your face when washing.
  • Do not pop the pimples.
  • Refrain from touching your face.
  • Wash your hands thoroughly before applying gels and creams.
  • Avoid using oil-based products.
  • Avoid stress and anxiety.
  • Keep your skin cool and dry.
  • Avoid irritants such as acne concealers and greasy cosmetics.
  • Protect your skin from too much exposure from the sun.
  • Avoid pressure on your skin.

What treatments are available for acne?

Acne treatment depends on the severity and how often acne occurs.

  1. Mild acne

OTC medicines, gels, soap and cream can treat mild acne. OTC medicines may contain active ingredients like:

  • Salicylic acid- assist the breakdown of whiteheads and blackheads
  • Azelaic acid- to strengthen the cell that lines the follicles; stop the production of sebum; reduces bacterial growth
  1. Moderate to severe acne

Your doctor may prescribe the following:

  • Antibiotics– It works by killing the bacteria and fights the inflammation. It is best used with topical benzoyl peroxide.
  • Injections- A specialist may inject diluted corticosteroid to treat inflamed cyst.
  • Oral contraceptive- It is a long-term treatment for acne.
  • Topical medicines like Retinoid- It come in the form of gels, creams and lotions.
  • Therapies like chemical peel, laser and whiteheads and blackhead extractions.

Common acne medicines