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Symptoms of Rheumatoid Arthritis

Symptoms of Rheumatoid Arthritis

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Rheumatoid arthritis is a chronic inflammatory condition that affects more than just the joints. Some people can suffer damage to many different body systems, including the skin, eyes, lungs, heart, and blood vessels.

The immune system mistakenly attacks your body’s tissues when rheumatoid arthritis occurs. Rheumatoid arthritis, in contrast to osteoarthritis, causes swelling of your joints that can eventually result in bone erosion and joint deformity, instead of the wear-and-tear damage associated with osteoarthritis.

The inflammation associated with rheumatoid arthritis can also damage other parts of the body. While new treatments for severe rheumatoid arthritis have improved dramatically, they still can lead to severe disabilities.

back pain

What Are The Symptoms Of Rheumatoid Arthritis?

Symptoms of Rheumatoid Arthritis may include:

Early rheumatoid arthritis tends to affect your smaller joints first, particularly the joints that attach your fingers to your hands and your toes to your feet. As it progresses, the symptoms often spread to the shoulders, hips, elbows, ankles, knees, and wrists. In most cases, symptoms occur in the same joints on both sides of your body. 

Risk Factors for Rheumatoid Arthritis

Factors that may increase your risk of rheumatoid arthritis include:

  • Family history – if a member of your family has rheumatoid arthritis, you may have an increased risk of the disease.
  • Your sex – women are more likely than men to develop rheumatoid arthritis.
  • Age – rheumatoid arthritis can occur at any age, but it most commonly begins in middle age.
  • Excess weight – people who are overweight appear to be at a somewhat higher risk of developing rheumatoid arthritis.
  • Smoking – cigarette smoking increases your risk of developing rheumatoid arthritis, particularly if you have a genetic predisposition for developing the disease. Smoking also appears to be associated with greater disease severity.

Diagnosis for Rheumatoid Arthritis

Rheumatoid arthritis can be difficult to diagnose in its early stages because the early symptoms imitate those of many other diseases. There is no one blood test or physical finding to confirm the diagnosis. During the physical exam, your doctor will check your joints for swelling, redness, and warmth. Your doctor may also check your reflexes and muscle strength.

Medications Used For Kidney Infection

Treatment for Rheumatoid Arthritis

There is no specific cure for rheumatoid arthritis. However, clinical studies indicate that remission of symptoms is more likely when treatment begins early with medications known as disease-modifying antirheumatic drugs (DMARDs).

Medications can be used for rheumatoid arthritis:

The types of medications recommended by your doctor will depend on the severity of your symptoms and how long you’ve had rheumatoid arthritis. Always ask for instructions when taking certain medications. 

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What Condition Does Indomethacin Treat and Its Price?

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Indomethacin is an FDA-approved prescription used to relieve inflammation and pain. The effect of Indomethacin helps to decrease swelling and pain. This comes as a capsule for oral use.

What condition does Indomethacin treat?

Indomethacin is mostly prescribed by many doctors to use in adults for the treatment of a wide range of disorders such as:

Indomethacin is also known as a nonsteroidal anti-inflammatory drug (NSAID). This blocks the production of certain natural substances that your body makes which causes inflammation.

How does Indomethacin work?

Indomethacin blocks the action of a substance in the body called cyclo-oxygenase (COX). COX is involved in the production of various chemicals in the body. Some of which are known as prostaglandins. These are produced by the body in response to injury and certain diseases and conditions. It causes inflammation, pain, and swelling. Indomethacin blocks the creation of these prostaglandins and as a result, this is effective at decreasing pain and inflammation.

What is the dosage of Indomethacin?

This medicine is to be taken by mouth usually 2 to 3 times a day or as directed by your doctor. Swallow the capsule as a whole with a full glass of water. Do not lie down for at least 10 minutes after taking this medicine. If stomach upset happen, take it with food, antacid, or milk. The recommended dosage will depend on your medical condition and response to the treatment. To reduce the risk of other side effects, take the medicine at the lowest effective dosage for the shortest time. Do not increase your dose or use this drug more often or for longer than the prescription. Remember to take this prescription in the same way and at the same time each day.

Before you notice the full benefits, it may take up to 4 weeks when this drug is taken regularly in certain conditions. If you are taking this on an as-needed basis, remember that pain medications work best if they are used as the first signs of pain occur. Let your doctor know if your condition does not improve or if it gets worse. If you missed a dose, call your doctor for instructions. Do not double the dosage to make up for the missed dose.

What are the precautions in using Indomethacin?

  • Indomethacin may cause dizziness that may affect your capacity to operate machinery or drive safely. Do not operate machinery or drive until you know how this medicine affects you and you are sure it won’t affect your performance.
  • The lowest effective dose of this medicine will be given by your doctor. It may be for the shortest possible time needed to relieve your symptoms. This is to minimize the chances of any side effects. It is important not to exceed the prescribed dose.
  • Certain medicines should not be used during breastfeeding or pregnancy. On the other hand, other medications may be used without harm in breastfeeding or pregnancy if the benefit to the mother outweighs the risks to the unborn baby. Inform your doctor if you are planning a pregnancy or pregnant, before using any medication.
  • Let your doctor if you ever had an allergic reaction to this drug. Tell also if you have any allergies. This medication may contain an ingredient that causes an allergic reaction.
  • Use this with caution in people with a history of disorders that affects the stomach, who have inflammatory bowel disease, decreased kidney or liver function, heart failure, or high blood pressure.
  • For people with a history of stroke, heart disease, poor blood circulation in the arteries of the legs, high cholesterol levels, diabetes, or smoker, this prescription should as well be sued carefully.
  • Indomethacin is not recommended for use in children, people with nasal polyps, active peptic ulcers, severe kidney or liver failure, severe heart failure, or in people who are allergic to aspirin.
  • If you have any overdose signs, call for emergency medical assistance right away or call your doctor.

Price of Indomethacin vs. Tivorbex

The generic Indomethacin is an inexpensive NSAID that provides prolonged pain relief. It only costs:

  • $0.06 per unit of 25 mg capsule
  • $36 for 60 caps of 25 mg capsule

The brand name Tivorbex costs:

  • $1.08 per unit of 25 mg capsule
  • $65 for 60 caps of 25 mg capsule
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Medication that is a Non-Steroidal Anti-inflammatory Drug (Painkiller)

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Pain can be of different types. It can be due to fever, stiffness, swelling from inflammation etc. It enables us to do our daily work. There are different painkillers in the market to relieve pain.

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID). It helps to reduce pain in above conditions. The FDA first approved the drug in January 1965.

How does Indomethacin work?

Indomethacin belongs to a group of drugs known as NSAIDs. Hormone prostaglandin is a natural chemical produced in the body. This leads to fever and pain due to inflammation. The above drug blocks the synthesis of a certain enzyme. The enzyme is responsible to produce prostaglandin. Low levels of this hormone provides relief from fever, pain, and swelling.

How to take Indomethacin?

Above drug is available in the form of a capsule of 25 mg. The dosage depends on the type of pain, age, and tolerance of the patient.

Adult: –

  • Initial dose- 25 mg to 75 mg (one time or in 2-3 divided doses) in a day.
  • Maximum single dose-100 mg.
  • Maximum dose- 200 mg in a day.

Children: –

  • Child <2 years: – Not recommended for children younger than 2 years with some exception.
  • Child >2 years: the dose is decide as per the need of the patient.

Comments: –

  • Your Doctor may need to adjust the dose.
  • How often you should take it, depends on the condition.
  • Take all the doses in time to get best results.
  • Take it with food or antacid. This avoids stomach upset.

What are the uses of Indomethacin?

Indomethacin is used to reduce pain, fever, and inflammation in following conditions.

  • Rheumatoid arthritis.
  • Osteoarthritis.
  • Gouty arthritis.
  • Shoulder pain.
  • Joint stiffness.
  • Degenerative heap disease.
  • Ankylosing spondylitis.
  • juvenile arthritis.
  • A migraine.
  • Primary exertion headache.
  • Pain due to a kidney stone.

Clinically it is useful in the following conditions:

  • Delay premature labor.
  • Reduce amniotic fluid in the sac.
  • To close patent ductus arteriosus post-delivery of a child.

It helps to ease the pain.

Your doctor may use it for some other reason. Talk with the doctor.

Reduced symptoms help you to do routine activities.

What are the precautions in taking Indomethacin?

Talk to your Doctor prior to take the above drug. Certain conditions may create problems. Inform your doctor if you have any of the following conditions.

  • History of asthma.
  • Liver disease.
  • History of Parkinson’s disease.
  • Psychotic disorder.
  • Epilepsy.
  • Kidney disease.
  • high blood levels of potassium.
  • Recent heart bypass surgery.
  • Inflammation of rectum or anus.
  • Heart disease.
  • Bleeding disorders.
  • Stomach or intestinal ulcer.

Inform your doctor if you are,

  • In the third trimester of pregnancy.
  • Feeding mother.
  • Allergic to above drug.
  • Taking other NSAIDs.

Inform regarding all other medicines you take.

Your doctor may use it for some other reason. Ask your doctor.

Cost of Indomethacin (Generic and Brand)

Brand drugs need to spend a huge amount of research and development. They also spent on pricing, packaging, and advertising. This increases their selling cost.

Generic medicines do not include these expenditures. So they are cheaper as compared to Brand drugs.

Cost of Generic Indomethacin.

-Pack of 60 capsules costs $ 22.22, per unit cost is $ 0.37.

Cost of Brand Tivorbex.

-Pack of capsules costs $ 306.19, per unit cost is $ 5.10.