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What Are Signs Of Acute Pain

What Are Signs Of Acute Pain?

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There are several signs associated with acute pain since the term itself is quite vague and broad. Conversely, if you’re experiencing acute pain, it’s important to take some time off to rest and receive sufficient treatment. After all, the only way to get back on track as soon as possible is to fully heal. Failing to receive proper care can only lead to complications and even more time off the field to do the things you want to get done.

What Is Acute Pain?

Acute pain is a sensation you feel as soon as you experience an injury. For instance, if you slice open a finger while chopping vegetables, break a bone, or fall down the stairs, you are going to feel acute pain. It’s a signal from your body that it has just undergone physical trauma. Commonly, the pain stops once the injury heals.

back pain

Signs of Acute Pain

Acute pain tends to be of relatively short duration. The most common signs of acute pain may include:

Common Causes of Acute Pain

Besides blunt trauma examples, a person could also suffer from acute pain because of any of the following reasons:

  • Sprains and strains of a body part
  • Going to the dentist
  • Giving birth
  • Infections on a cut
  • Getting burned
  • Slipping and falling
  • Menstrual cramps
  • Passing a kidney stone
  • Bumping a body part against a hard surface

The range of pain can vary significantly depending on what’s causing it or the severity of the injury. 

Effects of Acute Pain 

The effects of acute pain extend far beyond an injured body part. Debilitating pain will affect other areas of a person’s life as well. People suffering from severe pain often find it difficult to sleep or lose their appetite because of it. In a worst-case scenario, it may lead to depression or addiction to pain medication, depending on where the pain is located.

losing weight

Acute Pain Treatment 

Every person’s pain is unique, just as every person’s life is unique. It is also important to provide them with the right pain management treatments and medications. People differ in their pain treatment to ensure that they receive effective treatment based on their unique characteristics.

Initial treatment may include some of the following:

  • Opioid medications
  • Muscle relaxant medications
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Stress reduction
  • Resting the affected part of the body
  • Application of heat or ice
  • Physical therapy
  • Exercise
  • Bioelectric therapy 

A secondary tier of treatments may include

Recommended medication:

  • Tramadol – this drug is a narcotic-like pain reliever that is effective in managing acute and chronic pain. 
Depression

Depression

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Depression is a common and serious medical illness. Having this condition negatively affects the way you think and act as well as how you feel. Being depressed causes feelings of sadness or a loss of interest in the things you once enjoyed. Depression might lead to a variety of physical and emotional problems. It can also lessen your ability to function in your everyday life.

This condition is different from feeling down or just sad for a few hours or a couple of days. It is also different from experiencing sadness after a difficult event or grief over losing a loved one. People with depression cannot just pull themselves out of it.

There are different types of depression and it includes:

  • Major depressive disorder
  • Dysthymic disorder
  • Psychotic depression
  • Postpartum depression
  • Seasonal affective disorder
  • Bipolar depression

What Causes Depression?

There are various reasons why a person may have depression:

  • Family history: If you have a family history of depression, you may be more at risk.
  • Hormone levels: Changes in hormones especially in women occur. The hormones progesterone and estrogen change during pregnancy, menstrual cycle, postpartum period, or menopause.
  • Stress: Stressful life events such as work responsibilities, trauma, abuse, or poverty may lead to depression.
  • Medical problems: Dealing with a person with a serious health problem such as cancer may lead to depression. Some medical conditions such as stroke, hypothyroidism, or Parkinson’s disease may cause changes in the brain that can trigger depression.
  • Pain: Those who feel physical or emotional pain for long periods are much more likely to develop depression. The pain may come from an accident, chronic health problems, or trauma.

Signs and Symptoms of Depression

If you have experienced most of the following symptoms each day over 2 or more weeks, you may meet the criteria for a depression diagnosis. Some of the symptoms of depression include:

  • Feeling of hopelessness
  • Lack of energy
  • A persistent feeling of sadness or loneliness
  • Difficulties with attention or concentration
  • Eating too little or too much
  • Getting too little or too much sleep
  • Feelings of guilt and worthlessness
  • Loss of interest in enjoyable activities
  • Thoughts of suicide or death

Depression may look different from a different person and the intensity of the symptoms also varies. If you have depression, may have experienced every symptom. This condition might appear differently in children than in adults. Some symptoms in children can include anxious behavior or anxiety.

Risk Factors of Having Depression

The following are the listed factors of getting the disease:

Areas affected by the condition:

Accordingly, when it comes to places/areas, United States, China, India, Brazil, and Bangladesh have the highest rate of depression. 

People who are at risk:

Depression may affect everyone even an individual who seems to live in relatively ideal environments. Various factors can play a part in depression:

  • Genetics: Depression can run in families.
  • Personality: People who are easily overwhelmed by stress, with low self-esteem, or who are normally pessimistic appear to be more likely to experience depression.
  • Biochemistry: Variances in certain chemicals in the brain may contribute to symptoms of depression.
  • Environmental influences: Constant exposure to violence, poverty, or abuse may make some individuals more susceptible to depression.

Safety Precautions

If you do have depression, you can do a few things to keep it from getting worse:

  • Avoid alcohol and recreational drugs.
  • Stick with your treatment plan. If you are on medication, take it as prescribed. Don’t skip therapy sessions. Let your doctor know if isn’t working for you.
  • Try ways to fight stress like yoga or meditation.
  • Spend time with family and friends. Do things that keep you connected to others.
  • Don’t make big life decisions on a day when you’re feeling down.
  • Know yourself and pay attention to the things that seem to make your symptoms worse. Keep records and let your doctor know about it.
  • Talk to your doctor about medication that can stop depression from coming back.

Treating Depression

Depression is curable with the majority of those who search for treatment showing progress. The most commonly used treatments are psychotherapy, antidepressant medication, or a combination of the two.

The treatment depends on the severity, pattern, the history of the illness, and persistence of depressive symptoms. As with several diseases, early treatment is more effective and helps avoid the likelihood of serious reappearances. Depression should be cured by a physician or qualified mental health professional.

Treat Depression and Quit Smoking With Bupropion (Wellbutrin)

Treat Depression and Quit Smoking With Bupropion (Wellbutrin)

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Bupropion is a generic form of the brand name Wellbutrin. It is an Antidepressant. It is used in the treatment of Depression and other mental / mood disorders.  Zyban brand of bupropion is also helpful in smoking cessation. It is very helpful to quit smoking. It does not show much sexual side effects as compared to other antidepressants. It is also used in some other purposes which is not listed in the medication guide. It is available as oral tablets. Some other Brands of Bupropion are Zyban , Wellbutrin XL, Wellbutrin SR , etc.

9 Advantages of Bupropion

Depressed girl smoking
Depressed girl smoking
  1. It is energizing due to some stimulant effects.
  2. It helps to cover ADHD symptoms.
  3. It is used by the people who want to quit smoking.
  4. It is also used to suppress appetite.
  5. It does not show sexual side effects eg depressed libido.
  6. Using the above drug do not put weight gain in a patient.
  7. Patient does not face somnolence [sleepiness].
  8. It is as effective as other prescribed antidepressant with all above advantages.
  9. No cardiac toxicity seen.

Working of Bupropion

Its working is not yet understood completely. It is a complex action. In smoking cessation, it binds the receptor at which nicotine normally binds. It is said to be antagonist at nicotinic receptors. Thus, reduces craving to smoking. By using for a prescribed period, patient quit the habit of smoking.

Common side effects:

  • Anxiety (nervousness) or confusion.
  • Irregular heartbeat.
  • Sleeping restless and shaking.
  • Dry mouth.
  • Dizziness, headache
  • Gastrointestinal upset.
  • Seizure
  • Weight loss, skin problems like, rashes, itching, sweating etc.
  • Vision changes.

LIMITATIONS

  • One should not take bupropion in following condition.
  • Seizures disorder or epilepsy.
  • Eating disorders.
  • In combination with zyban to quit smoking.
  • If MAO inhibitor is used in past 14 days.
  • When using for first time, it can produce suicidal thought. So patient should be observed primarily.
  • Should not use if one has a habit of drinking alcohol.

One should take precaution, as it may be not suitable in some people with certain condition like ,

  1. A history of head injury, brain tumor.
  2. Diabetes.
  3. Kidney or liver disease.
  4. In pregnancy as there is no study or evidence of harm in unborn baby.
  5. Brest feeding mother, as it can pass into breast milk.

Take medicine as and when prescribed by doctor. Swallow it with water or other liquid without breaking or chewing it. Do not change the quantity without doctor’s permission. In case of smoking cessation, nicotine patches or gum can be used to overcome the eagerness of smoking. One should not take over dose of Bupropion as it can be fatal . One should avoid drinking alcohol as it increases risk to seizures.

So, we can come to a conclusion from the above information that Bupropion is really effective in case of Depression and to quit smoking. It also shows many advantages over other Antidepressants which are prescribed. But there are some adverse effects which has to be considered so that it does not cause any harm to a patient .

Dapoxetine for Treating PE

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Dapoxetine is a safe and effective medication designed specifically for men having problems with premature ejaculation. It increases the time for men to ejaculate and improve the control over ejaculation. Dapoxetine is initially created as an antidepressant but its fast-acting property makes it suitable in treating premature ejaculation. It is fast-absorbing and eliminates from the body within a few hours.

What condition does Dapoxetine treat?

Dapoxetine is a prescription medication that comes in a tablet form. It is designed for treating premature ejaculation in men aged 18 to 64 years of age. This tablet is only prescribed after your doctor will make a careful assessment making sure that this drug is appropriate for you.

How do Dapoxetine works?

  • Dapoxetine tablet is a short-acting selective serotonin reuptake inhibitor or SSRI. It works by increasing the activity of serotonin in the brain.
  • Premature ejaculation or PE is defined as when a man reaches orgasm and therefore, ejaculates very quickly or too soon than his partner would like during sex.
  • No one really knows why one person experience PE more than another. Though the exact cause is unknown, serotonin may play a role.
  • Serotonin is a chemical that has a wide variety of functions in the body. It is often called as a happy chemical. It is a neurotransmitter that is involved in the passing of messages between nerve cells.
  • High serotonin in the brain increase the time for men to ejaculate. Low amount of this happy chemical can shorten ejaculation time which can lead to premature ejaculation.
  • Dapoxetine increases the activity of serotonin in the brain which helps increase the time it takes for men to ejaculate and to have control over ejaculation. When taken 1-3 hours before sexual activity, Dapoxetine increases the sense of control and sexual satisfaction in men for up to 2 hours.
  • According to research, an estimated one-third of all men will experience premature ejaculation at some point in their life.

What is the dosage of Dapoxetine?

  • Dapoxetine comes in a tablet form for you to take orally. The recommended starting dose is 30 mg tablet taken 1-3 hours before sexual intercourse. Your doctor may increase your dose to 60 mg only if 30 mg dose is insufficient.
  • Since this drug is fast-acting, it may be effective at the first dose when taken 1-3 hours before sexual intercourse. The duration of the effect lasts for an average duration of 1-2 hours.

How to take Dapoxetine?

  • Take Dapoxetine exactly as directed by your physician. You can also read the information leaflet before you start the treatment. The information leaflet will provide you with a full list of the side effect which you may experience from taking it.
  • Take the tablet with a full glass of water. Swallow the tablet whole. Do not chew or crush the tablet because it has a bitter taste.
  • Do not take more than one tablet within 24 hours. Take it only before you anticipate having sex. It is not intended for regular daily use.

What are the precautions in taking Dapoxetine?

migraine with aura
  • This medicine is not recommended for men who are not diagnosed with PE or premature ejaculation.
  • It is not suitable for teenagers under 18 years of age or anyone with a history of psychiatric illness, heart disease or fainting.
  • Dapoxetine is also not recommended for people with:
    • Uncontrolled epilepsy
    • History o fainting
    • Significant heart problems such as heart block, heart attack, angina pectoris, heart failure, sick sinus syndrome or heart valve problems
    • Psychiatric illness such as schizophrenia
    • Severe liver or kidney problems
    • History of bipolar disorder, severe depression mania or hypomania
    • Hereditary problems of galactose intolerance, glucose-galactose malabsorption or the Lapp lactase deficiency
  • Lower dose and extra monitoring are needed for patients:
    • Who are taking blood clotting medications such as anticoagulant like warfarin
    • Who suffers from epilepsy
    • Who have kidney or liver problems
    • Have history of a blood clot or bleeding disorder such as hemophilia
    • Who has a closed angle-glaucoma or have raised pressure in the eyeball
    • Have a history of low blood pressure
    • Who are dehydrated due to prolonged diarrhea, excessive sweating, vomiting as this medication can increase the chances of dehydration
  • Your doctor needs to check your progress so make sure you keep your follow-on appointments with your doctor.
  • Please check with your doctor if you buy or use any other medicines. Some medications can interact with Dapoxetine making it less effective or sometimes worsen the side effects.
  • Medicines like ritonavir, Itraconazole and Nelfinavir can increase your risk from side effects.
  • Do not take Dapoxetine with PDE5 medications such as Sildenafil, Tadalafil or Vardenafil as these can make you feel dizzy or more likely to faint.
  • Just like any other premature ejaculation medication, Dapoxetine can also cause unwanted side effects although not everyone experiences them. The unwanted side effects often improve as your body becomes adjusted to the medicine. Very common side effects include:
    • Nausea
    • Dizziness
    • Headache
  • Common side effects are:
    • Flushing
    • Blurred vision
    • Abnormal dreams
    • Feeling tired or sleepy
    • Reduced sex drive
    • Increase blood pressure
    • Excessive sweating
    • Erectile dysfunction
  • Uncommon side effects are:
    • Dilated pupils
    • Failure to ejaculate
    • Faster or slower heartbeat
    • Feeling dizzy after exertion
    • Urgent need to defecate
    • Teeth grinding
  • You are more likely to have bleeding problems if you take this medication along with antiplatelet, anticoagulants, anti-inflammatory, and anti-psychotic medications.
  • Do not use higher than 30 mg if you are taking medicines like erythromycin, clarithromycin, fluconazole, and verapamil

Costs of Generic Dapoxetine vs Priligy

Dapoxetine is a generic drug and is cheaper compared with the brand name Priligy. Dapoxetine 60 mg cost $5.5 per unit price or $55 for 10 tabs. While the brand name Priligy cost $115.95 for 6 tabs or $38.65 per unit price.

Buy Venlafaxine

Venlafaxine

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Venlafaxine is a prescription antidepressant drug. It is a first-line therapy among patients with depression. It is also indicated for the treatment of conditions like:

  • Generalized anxiety disorder (GAD)
  • Social anxiety disorder, an extreme fear of interacting with other
  • Panic disorder, a sudden unexpected attack of worry and fear
  • Major depressive disorder
  • Melancholia, persistent depression and fear

Venlafaxine belongs to the group of drugs known as serotonin-norepinephrine reuptake inhibitors (SNRIs). It works by increasing the levels of serotonin in the brain. It also helps increases the level of norepinephrine, a natural chemical in the brain that acts together to relieve pain and to brighten the mood.

Why Buy Venlafaxine?

Venlafaxine is one of the most commonly used prescription anti-depressants in the U.S. It is the same active ingredient found in the brand names Trevilor, and Lanvexin. It is approved by the U.S FDA for the treatment of anxiety since 1993 and panic disorder in 2005. The generic Venlafaxine is always cheaper in cost than the brand names but both offer the same effectiveness.

How to Take Venlafaxine?

Take this medication exactly as directed by your physician. This drug comes in an immediate-release and an extended-release capsule. The usual starting dose is between 37.5 mg to 75 mg a day. Your doctor may gradually increase your dose to 225 mg a day. Continue taking this medication even if you feel well. It can take up to 2 months for you to feel the full benefit of this medication. Take this medication with food. Swallow the tablet whole with a glass of water. Remember that this medication can only control your depression. It will not cure your condition.

Things to Remember

  • This medication has a black box warning. Studies have found an increased suicidal thought among children and young adults.
  • Do not stop taking this medication. A sudden stop can lead to withdrawal symptoms such as sleep disorder, anxiety, nausea and vomiting.
  • Pregnant and breastfeeding women should not use this medication.
  • Discuss with your doctor the risk and benefits of using this medication.
  • Do not use this medication with a monoamine oxidase inhibitor (MAOI).
  • Combining NSAIDs, aspirin and warfarin with this drug may cause bleeding.
  • Seek medical attention right away in case of serious side effects such as seizures, abnormal bleeding and severe allergic reactions.
  • Avoid drinking alcohol because alcohol can augment the sleepiness effect of this drug.
Buy Mirtazapine

Moderating the Level of Certain Natural Chemicals To Treat Depression

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Mirtazapine belongs to the class of tetracyclic antidepressant. It is a noradrenergic and specific serotonergic antidepressant (NaSSA). Remeron is the brand name drug of above drug in market. This drug treats depression by moderating the level of certain natural chemicals. It treats anxiety disorder. It was launched in the United States in 1996. This drug is also a good choice for Patients showing anxiety or insomnia. 

How does Mirtazapine work?

Mirtazapine is an oral medicine used in the treatment of depression. It exhibits both noradrenergic and serotonergic activity. It works by affecting the balance of the neurotransmitters (NT) such as serotonin and noradrenaline.

These NTs act as a messenger between the nerve cells in the brain. In depression, it is thought that there may be a decreased amount of above NT. The mood lightens if these chemicals are released at the nerve ending.  If they are bound to the nerve ending in the brain, then this may lead to a depressed mood.

Mirtazapine blocks the receptors called alpha-2 receptors on nerve cells in the brain. Generally NT bind to this receptors. Thus Mirtazapine avoids binding of nerve cells in the brain to the alpha-2 receptors. This relieves the depression and lightens the mood.

What are the uses of Mirtazapine?

Mirtazapine is an antidepressant drug which works on the nerve ending in the brain. It treats various symptoms of major depressive disorder [MDD]. It helps in improving the following symptoms.

  1. A depressed mood like feeling sad, empty or tearful.
  2. Feeling hopeless or guilty.
  • Suicidal thoughts.
  1. Feeling nervous.
  2. Low energy.
  3. Trouble concentration.
  • Unusual sleeping or eating habits.
  • Psychomotor retardation

This drug helps to come out of above symptoms and behavior. It does not affect cholinergic or dopaminergic receptors.

How to take Mirtazapine?

Mirtazapine comes in the form of a tablet of strength 7.5mg, 15mg & 30mg. General dosage for Mirtazapine is 15 mg/ day. This is a single dose to take preferably at night. Your Doctor may change the dose depending on

  • Your condition and
  • How you respond to the lower dose.

These are orally disintegrating tablets. Place it on the tongue as soon as you peel the foil.  It will dissolve in seconds. You can swallow it with saliva. No need to drink water.

What are the precautions in taking Mirtazapine?

It is necessary to take precautions with Mirtazapine in certain condition discussed below.

  1. Avoid this drug with monoamine oxidase (MAO) inhibitor.
  2. Keep the difference of 2 weeks prior and after you take MAO inhibitor treatment.
  3. Inform your doctor in case of other medications you take. This may avoid risk of side effects and interaction.
  4. It isn’t suitable to use this drug in children.
  5. Elder people may need some adjustments in the dose to avoid side effects.
  6. There are no adequate proofs to use the drug in pregnancy or breast feeding.
  7. Tell your doctor regarding Heart problems or other metabolic disorders.

Cost of Mirtazapine.  [Generic & Brand]

The brand version of Mirtazapine is Remeron. The generic and brand Remeron differ in their price both in physical and online pharmacy. Their effect remains same as the basic active ingredient is Mirtazapine.

# Cost of generic Mirtazapine.

-The 7.5mg tablet is $ 0.37 per unit and pack of 30 tablet is $11.

-15 mg tablets are $0.73 per unit and pack of 30 tablets is $22.

-30mg tablet is $ 1.17 per unit and pack of 30 tablets is $ 35.

# Cost & Brand Remeron.

-15mg tablet is $ 6.49 per unit & pack of 30 tablet is $ 194.60.

-30mg tablet is $ 6.67 per unit & pack of 30 tablet is $ 200.24.

This shows the cost difference between the generic and the brand version. It is always beneficial to go with Generic.