Tag Archives: Cyclosporine

Psoriasis

Psoriasis Treatment

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Psoriasis is a scaly and red skin disease characterized by patches of red, itchy skin most commonly on the knees, elbows, trunk, and scalp. There is no cure for this long-term (chronic) disease. The condition goes through cycles, flaring for a few weeks or months, then subsiding or remitting for a while. You can manage symptoms with treatments. In addition, lifestyle habits and coping strategies can help you cope with psoriasis better.

There are several types of psoriasis including:

  • Plaque psoriasis
  • Nail psoriasis
  • Guttate psoriasis
  • Inverse psoriasis
  • Pustular psoriasis
  • Erythrodermic psoriasis
  • Psoriatic arthritis
Skin rashes

Symptoms of Psoriasis

The symptoms of Psoriasis can vary from person to person. Common symptoms may include:

  • Thickened, pitted, or ridged nails
  • Swollen and stiff joints
  • Dry, cracked skin that may bleed or itch
  • Itching, burning, or soreness
  • Red patches of skin covered with thick, silvery scales
  • Small scaling spots (commonly seen in children)

Causes of Psoriasis

Research has a general idea of two key factors that cause Psoriasis:

  • Genetics: The condition may run in families. Having one parent with psoriasis increases your risk of getting the disease, and having two parents with psoriasis increases your risk even more.
  • Immune system: Psoriasis is an autoimmune disease. Autoimmune diseases occur when the body attacks itself. Psoriasis is caused by white blood cells known as T cells attacking your skin cells. Usually, white blood cells are deployed in the body to attack and destroy invading bacteria and mount a defense against infections. Skin cell production goes into overdrive due to this mistaken autoimmune attack. New skin cells are developed too quickly as a result of accelerated skin cell production. The cells are pushed to the skin’s surface, where they collect.

Diagnosis for Psoriasis

Two tests or examinations may be needed to diagnose psoriasis. 

  • You will be asked about your health and your skin, scalp, and nails will be examined. 
  • A biopsy of a small piece of skin may be taken by your doctor. This helps determine the type of psoriasis and rules out other disorders.  

Treatment and Medication for Psoriasis

Psoriasis treatments aim to reduce the rate at which skin cells grow and remove scales. Treatment depends on the severity of psoriasis and how responsive it has been to previous treatments. You might need to try different drugs or a combination of treatments before you find an approach that works for you. Usually, however, the disease returns.

1. Topical therapy

therapy at clinic

2. Light therapy

  • Sunlight
  • UVB broadband
  • UVB narrowband
  • Psoralen plus ultraviolet A (PUVA)
  • Excimer laser

3. Oral or injected medications

Medications usually recommended used for the treatment of Psoriasis:

If you are considering dietary supplements or other alternative therapy to ease the symptoms of psoriasis, consult your doctor. Your doctor can help you weigh the pros and cons of specific alternative therapies. 

Buy Cyclosporine

What Condition Does Cyclosporine Treat and Its Price?

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Cyclosporine belongs to the class of medications known as immunosuppressants. This is available in 25mg and 100mg strengths for oral use. The Food and Drug Administration (FDA) has already approved this medication.

What condition does Cyclosporine treat?

Cyclosporine is a prescription medicine used to prevent organ rejection in people who have received a liver, kidney, and heart transplant. This medication may also be used to treat severe cases of rheumatoid arthritis and plaque psoriasis. This is usually taken along with other medications to allow your new organ to function normally. 

How does Cyclosporine work?

Cyclosporine decreases the activity of B and T-lymphocytes. These are white blood cells that are accountable for triggering and regulating immune responses. The usual role of these white blood cells is to provide defense against infection and foreign cells. This medicine stops the T-lymphocytes from creating substances called lymphokines. Lymphokines have various roles, including activating and attracting other immune cells. It also stimulates the creation of antibodies by B-lymphocytes. By discontinuing the T-cells from making lymphokines, Cyclosporine stops certain immune responses from happening.

If you have had an organ transplant, the cells of the donor will not be identical to the cells in your body. Consequently, your immune system will identify that the new cells are unlike and try to reject the transplanted tissue. This medication prevents this by destroying the activity of the cells in your immune system that may usually attack the transplanted tissue.

In psoriasis, it is thought that T-cells exaggerate to a stimulus in these conditions which causes the inflammation and scaling of the skin. Cyclosporine can be used in severely disabling and resilient forms of psoriasis to suppress the action of the T-cells and thus improve the scaling of the skin.

What is the dosage of Cyclosporine?

The dosage of this medicine your doctor prescribes will depend on several factors. These include:

  • Your age
  • The type and severity of the condition you’re using the medicine to treat
  • Other medical conditions you may have

Usually, your doctor will begin you on a low dose and adjust it overtime to reach the dose that is suitable for you. Your doctor will eventually prescribe the smallest dosage that provides the desired effect.

Cyclosporine is usually taken twice a day. It is to be taken by mouth and at the same time each day. You may take each dose with or without food. You should choose one or the other and take every dose that way. If you take it with food, eat the same amount and type of food each time you take it. Swallow the medicine as a whole do not chew or crush it. Follow the dosing schedule very carefully. Do not double the prescribed dosage to avoid some complications. Take this medication at the same time each day. If you missed a dose, call your doctor for instructions. Avoid taking two doses to make up for the missed one. 

What are the precautions in using Cyclosporine?

Use Cyclosporine with caution in:

  • Children and elderly people
  • People with decreased kidney and liver function
  • People with a high level of uric acid in their blood
  • Dermatitis patients with skin infections and psoriasis patients with malignant or pre-malignant skin conditions

This medicine should not be used in:

  • Children under 16 years of age except for preventing and treating transplant rejection
  • Nephrotic syndrome patients with uncontrolled infections, uncontrolled high blood pressure, or any kind of malignancy
  • Dermatitis and psoriasis patients with uncontrolled high blood pressure, abnormal kidney function, or uncontrolled infections
  • Rheumatoid arthritis patients with uncontrolled infections, abnormal kidney function, or uncontrolled high blood pressure
  • Uveitis patients with uncontrolled high blood pressure, uncontrolled infections, or abnormal kidney function

Pregnancy and breastfeeding:

  • This medication not recommended for use in pregnancy unless considered needed by your doctor. Seek more medical advice from your doctor.
  • This medication passes into breast milk. It might be harmful to a nursing infant. Those women who need to take Cyclosporine should not breastfeed. Ask for more medical advice from your doctor.

Cost of Cyclosporine vs. Neoral

The generic Cyclosporine is an inexpensive medication that only costs:

  • $0.73 per unit of 25 mg capsule
  • $22 for 30 caps of 25 mg capsule
  • $2.89 per unit of 100 mg capsule
  • $86.90 for 30 caps of 100 mg capsule

The brand name Neoral costs a lot more expensive which is:

  • $2.67 per unit of 25 mg capsule
  • $80.06 for 30 caps of 25 mg capsule
  • $9.72 per unit of 100 mg capsule
  • $291.47 for 30 caps of 100 mg capsule
Buy Cyclosporine

Medication That Treats Chronic Dry Eyes and Increase Tears Production

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Cyclosporine is a cyclic polypeptide of 11 amino acids. It is produced by a fungal species which has immune-suppressive properties. It shows specific action on T cells and the cellular immune response.

Dry eye is a condition in which a person doesn’t have enough tears that lubricate and nourish the eye. It is a condition caused by inflammation of eyes. Tears play an important role to maintain the health of the front surface of the eyes. It also helps to provide clear vision and reduce the risk of infection etc. Many vital functions are done by the tears. Dry eyes occur when the balance between the production and drainage of tear is disturbed.

Cyclosporine is an ophthalmic solution used to increase tear production in people with dry eye disease. It was approved by FDA in January 2003.

How does dose Cyclosporine work?

Cyclosporine belongs to the class of medications known as immune-suppressants. It helps to increase tear production in people with dry eye disease. It decreases swelling in the eye to allow the production of tears.

The solutions is thought to work locally in the eyes as a partial modulator of the immune system. A lymphocyte is a type of white blood cell of the immune system. A condition may occur where these cells may die and accumulate in the tear glands. Cyclosporine can reserve this condition and lead to increase in tear production. The treatment may take 3 to 6 months to shows increase in tears production.

What are the uses of cyclosporine?

  1. Cyclosporine is an immune-suppressive agent. It helps to treat chronic dry eyes that may be caused due to inflammation.
  2. Helps patient increase their eye’s natural ability to produce tears.
  3. Can help reverse a worsening dry eye.
  4. Allows your eye to produce the maximum amount of tears that it is capable of producing.
  5. It is very safe and won’t penetrate into the bloodstream to any significant levels.
  6. The medication may be prescribed for other uses ask your doctor for more information.

How to use the ophthalmic Cyclosporine?

Cyclosporine is available in the form of an ophthalmic solution of 3 ml bottles (strength 0.05%).

  • General Dose: – One drop of the above solution two times a day in each eye at a difference of 12 hours.
  • Children: – Safety and efficiency not established in the age group below 16 years.

Comments:–

  • It can be used with artificial tears allowing a 15-minute interval between products.
  • Use the drop at around the same times every day.
  • It comes in small bottles to be used for one dose.
  • Close your eyes for 2 minutes after installation.

What are the precautions in using Cyclosporine?

  1. Some important instruction has to be followed while using cyclosporine. Inform or ask your doctor if you are/ have.
  • Eye infection.
  • Punctal plug in your eye.
  • Herpes infection of the eye.
  • Pregnant.
  • Breastfeeding.
  • Allergic to Cyclosporine or any other medicine.
  1. Remove your contact lenses before installing Cyclosporine. Put them back 15 minutes later.
  2. Don’t use in a patient younger than 16 years of age.
  3. Close your eyes for 2 minutes.
  4. Inform your doctor about other drugs you take or other eye drops to avoid drugs interaction.
  5. Your eyes may sting or burn for a short time. It is normal. Inform your doctor if the condition persists for a long time.

Cost of cyclosporine (generic & brand).

Generic medicines does not need to spend much on research and development of the drug. Other costs like the commission to agents etc. are also saved due to direct sourcing from the manufacturer. Another cost-cutting method allows us to sell cheap generic medicine to our customers.

Brand drugs include cost spend on advertising packaging and pricing. It also spends a lot of amounts on advertising their brand name. So the brand medicine is always costlier.

Cost of Generic Cyclosporine.

1 Bottle of 3 ml of 0.05 % of Cyclosporine cost $ 24.

Cost of Brand sandimmune.

1 ampule of 5 ml (50 mg/ml) costs $ 64.80.