Cyclosporine belongs to the class of medications known as immunosuppressants. This is available in 25mg and 100mg strengths for oral use. The Food and Drug Administration (FDA) has already approved this medication.
What condition does Cyclosporine treat?
Cyclosporine is a prescription medicine used to prevent organ rejection in people who have received a liver, kidney, and heart transplant. This medication may also be used to treat severe cases of rheumatoid arthritis and plaque psoriasis. This is usually taken along with other medications to allow your new organ to function normally.
How does Cyclosporine work?
Cyclosporine decreases the activity of B and T-lymphocytes. These are white blood cells that are accountable for triggering and regulating immune responses. The usual role of these white blood cells is to provide defense against infection and foreign cells. This medicine stops the T-lymphocytes from creating substances called lymphokines. Lymphokines have various roles, including activating and attracting other immune cells. It also stimulates the creation of antibodies by B-lymphocytes. By discontinuing the T-cells from making lymphokines, Cyclosporine stops certain immune responses from happening.
If you have had an organ transplant, the cells of the donor will not be identical to the cells in your body. Consequently, your immune system will identify that the new cells are unlike and try to reject the transplanted tissue. This medication prevents this by destroying the activity of the cells in your immune system that may usually attack the transplanted tissue.
In psoriasis, it is thought that T-cells exaggerate to a stimulus in these conditions which causes the inflammation and scaling of the skin. Cyclosporine can be used in severely disabling and resilient forms of psoriasis to suppress the action of the T-cells and thus improve the scaling of the skin.
What is the dosage of Cyclosporine?
The dosage of this medicine your doctor prescribes will depend on several factors. These include:
Usually, your doctor will begin you on a low dose and adjust it overtime to reach the dose that is suitable for you. Your doctor will eventually prescribe the smallest dosage that provides the desired effect.
Cyclosporine is usually taken twice a day. It is to be taken by mouth and at the same time each day. You may take each dose with or without food. You should choose one or the other and take every dose that way. If you take it with food, eat the same amount and type of food each time you take it. Swallow the medicine as a whole do not chew or crush it. Follow the dosing schedule very carefully. Do not double the prescribed dosage to avoid some complications. Take this medication at the same time each day. If you missed a dose, call your doctor for instructions. Avoid taking two doses to make up for the missed one.
What are the precautions in using Cyclosporine?
Use Cyclosporine with caution in:
This medicine should not be used in:
Pregnancy and breastfeeding:
Cost of Cyclosporine vs. Neoral
The generic Cyclosporine is an inexpensive medication that only costs:
The brand name Neoral costs a lot more expensive which is: