Estradiol Valerate is the major estrogen secreted by ovary. It synthesized in the graffian follicle, corpus luteum and placenta from cholesterol. Estradiol Valerate is rapidly oxidized in liver to estrone, which is hydroxylated to form estriol. All these three forms are found in blood. It is the most potent of the three. Secreted in menstruating women under the influence f FSH and concentration of Estradiol Valeratein blood increases during follicular phase. After ovulation corpus luteum continues to secrete estrogens till about 2 days before menstruation. You can easily buy Estradiol Valerate here at Rx 2 Go Pharmacy.
How does Estradiol Valerate / Generic of Estrace work?
Estradiol Valerateis largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Estradiol Valerateis rapidly oxidized in liver to estrone, which is hydroxylated to form estriol. Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. Estrogens exercise feed back inhibition of FSH by direct action on pitituary as well as through hypothalamus.
Side effects of Estradiol Valerate / Generic of Estrace
The common side effects reported with Estradiol Valerateare changes in vaginal bleeding pattern, spotting, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis, change in amount of cervical secretion, changes in cervical ectropion, ovarian cancer, endometrial hyperplasia, endometrial cancer, tenderness, enlargement, pain, nipple discharge, galactorrhea, fibrocystic breast changes, nausea, vomiting, abdominal cramps and bloating.
Guidelines before using Estradiol Valerate / Generic of Estrace
Estradiol Valerateaccelerates prothrombin time and platelet aggregation time. Estrace causes a substantial increase in blood pressure. Estradiol Valeratetherapy may be associated with elevations of plasma triglycerides leading to pancreatitis and other complications. It should be used with caution in patients with impaired liver function and past history of cholestatic jaundice. Estrace can cause some fluid retention. Estrogens should be used with caution in individuals with severe hypocalcemia. Endometriosis may be exacerbated with administration of Estrace. It is contraindicated in women with asthma, diabetes mellitus, epilepsy, migraine or porphyria, systemic lupus erythematosus, and hepatic hemangiomas. The long-term use of Estradiol Valeratecan cause endometrial cancer, breast cancer, and ovarian cancer. Estrace should not be used during pregnancy. Administration of Estrace to nursing mothers decreases the quantity and quality of the milk. This should not be used in pediatric patients. Estradiol Valerate is contraindicated in abnormal genital bleeding, history of cancer of the breast, estrogen-dependent neoplasia, active deep vein thrombosis and pulmonary embolism.
What are the common dosages of Estradiol Valerate / Generic of Estrace?
The recommended dose of Estrace is 1 to 2 mg daily. Progestin should also be initiated along with Estradiol Valerateto reduce the risk of endometrial cancer.
Difference between Brand and Generic Estradiol Valerate
The active ingredient is Estradiol Valeratein both brand and generic forms because of which the mechanism of action and drug interactions are the same. The difference between brand and generic forms are packaging, pricing and the brand name. Generic variants are priced cheaper because there are no brand names associated with it as well as no expenses towards research and development. You can buy cheap Estrace medicine when it is sold as a generic variant.
Where and How to buy Estradiol Valerate / Generic of Estrace?
You can purchase Estrace medicine online from our pharmacy. When you order Estrace drug online from us, it will reach your doorstep without any hassles. You can also save more when you buy this online in more numbers with the volume discounts we offer.
Why is the price of Estradiol Valerate/ Generic of Estrace so cheap at Rx 2 Go Pharmacy?
At Rx 2 Go Pharmacy, we sell generic Estrace, which means that we do not have to spend heavily on research and development of the drug. We also source the drugs directly from the manufacturer thereby eliminating any additional costs such as commissions to agents etc. All the savings accrued through various measures translates to the cheaper price of prescription drugs at Rx 2 Go Pharmacy. You can also get additional price benefits by taking advantage of the volume discounts we offer.
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