Benazepril- Amlodipine combination is not used in the initial treatment of hypertension. Lotrel is administered in patients with collagen vascular disease and renal impairment to avoid agranulocytosis and angioedema. Benazepril is a non sulfhydryl Angiotensin converting enzyme (ACE) inhibitor. Amlodipine is a dihydropyridine calcium channel blocker. Amlodipine has slow oral absorption and hence does not show early vasodilator side effects. The oral bioavailability of Amodipine is high and it is very long acting. You can now buy Amlodipine here at Rx 2 Go Pharmacy.
How does Benazepril- Amlodipine / Generic of Lotrel work?
Benazepril is an Angiotensin converting enzyme inhibitor (ACE) inhibitor. ACE inhibitor inhibits the conversion of Angiotensin I to Angiotensin II. Angiotensin II is an octapeptide in plasma, which is obtained by a precursor plasma alpha globulin and is involved in electrolyte, blood volume and pressure homeostasis. Amlodipine is a calcium channel blocker. Amlodipine acts mainly by arteriolar dilatation and causes a fall in blood pressure. Amlodipine causes reflex sympathetic stimulation of heart that result in tachycardia, increased contractility, increased coronary blood flow and cardiac output.
Side effects of Lotrel
The common side effects reported with Lotrel are asthenia, fatigue, insomnia, nervousness, anxiety, tremor, decreased libido, flushing, hot flashes, rash, skin nodule, dermatitis, dry mouth, nausea, constipation, dyspepsia, hypokalemia, back pain, muscle cramps, polyuria and impotence.
Guidelines before using Benazepril- Amlodipine
Lotrel is not recommended in patients with severe renal impairment. The concomitant administration of Lotrel and potassium supplements or potassium sparing diuretics can increase the levels of potassium in the blood. In patients taking diuretic along with Lotrel, there is a chance of developing hypotension. Hence it is advisable to discontinue diuretic before Lotrel treatment or take additional salt supplements. The co-administration of lithium and Benazepril- Amlodipine should be followed by a continuous monitoring of serum lithium levels as it can lead to lithium toxicity. Lotrel should be administered with caution in patients with hepatic impairment. It is not advisable to consume the Lotrel during pregnancy as it can lead to fetal death. Lotrel is not recommended in nursing mothers and in pediatric patients. The initial dose of Lotrel should be low in elderly patients.
What are the common dosages of Lotrel?
The recommended starting dosage of Benazepril is 10-40mg and of Amlodipine 2.5-10mg once daily.
Difference between Brand and Generic Benazepril- Amlodipine
The Brand and generic Lotrel contains Benazepril and Amlodipine as active ingredients. The difference between brand and generic forms are packaging, pricing and the brand name. The generic version is always cheaper in cost. The generic and brand forms acts in the same way. You can buy cheap Lotrel pills when it is sold as a generic variant.
Where and How to buy Benazepril- Amlodipine / Generic of Lotrel?
You can purchase Lotrel medicine online from our pharmacy. When you order Lotrel drug online from us, it will reach your doorstep without any hassles. You can also save more when you buy Lotrel online in more numbers with the volume discounts we offer.
Why is the price of Benazepril- Amlodipine / Generic of Lootrel so cheap at Rx 2 Go Pharmacy?
Being a generic drug, there are no costs involved in research and development activities. We also source the drugs directly from approved manufacturers. Buying in bulk helps us in getting volume discounts. All these savings translate as cheaper price of prescription drugs at Rx 2 Go Pharmacy.
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